Gout and Hyperuricemia

Introduction: hyperuricemia and gout.

The pathophysiology of gout is well understood, and effective treatments for acute gout and hyperuricemia leading to gout are widely available. Nonetheless, many patients suffer from severe tophaceous gouty arthritis, adverse effects of medications for gout, and inadequate treatment of hyperuricemia. The incidence of gout is rising in both men and women. The diagnosis and treatment of gout are ...

Gout. Novel therapies for treatment of gout and hyperuricemia

In the past few decades, gout has increased not only in prevalence, but also in clinical complexity, the latter accentuated in part by a dearth of novel advances in treatments for hyperuricemia and gouty arthritis. Fortunately, recent research reviewed here, much of it founded on elegant translational studies of the past decade, highlights how gout can be better managed with cost-effective, wel...

Gout and Hyperuricemia: an Historical Perspective

Gout is a common disorder of uric acid metabolism. A disease of antiquity its’ often dramatic presentation and unique manifestations have been familiar for eons to clinicians and to its sufferers. Effective modern therapies may have downgraded its status, yet it’s long, rich history remains a source of fascination, indeed entertainment to those with an interest in the pathophysiology of disease...

cohorts taught us about hyperuricemia and gout ?

The cohorts based at Framingham (MA, USA) have, arguably, contributed more to the understanding of human health and disease than any other epidemiologic study. Originally started as a single cohort of 5209 men and women in 1948, The Framingham Heart Study (FHS) was supplemented in 1971 by a second cohort of 5124 men and women, consisting of the offspring of the original cohort and their spouses...

Gout and Hyperuricemia in Chronic Kidney Disease